Clinical Biochemistry (also known chemical pathology) is the study of chemical and biochemical mechanisms of the body in relation to disease, mostly through the analysis of body fluids such as blood or urine.
In many diseases there are significant changes in the chemical composition of body fluids such as the raised blood enzymes due to damaged cardiomyocytes after a heart attack; or a raised blood sugar in diabetes mellitus due to lack of insulin. Tests are designed to detect these changes qualitatively or quantitatively compared to results from healthy people.
Clinical chemists use a wide range of analytical techniques for example spectrophotometry, ELISA, Immunochemistry, Nephelometry, Flame Photometry, Ion selective electrodes, Electrophoresis, Flowcytometry etc. for evaluation of patient samples. The results so obtained play pivotal role in establishing diagnosis, planning treatment modalities and projecting the possible prognosis and thus has key role in patient care. Highly specialized and sophisticated techniques such as Polymerase chain reaction, Restriction fragment length polymorphism, Mass spectrometry, confocal microscopy help in diagnosis of rare disorders which are otherwise difficult to diagnose clinically or the confirmatory diagnosis is difficult to establish. All the assays are closely monitored through highly sophisticated and standardizes quality control process which included predefined standard operating protocols for calibration and quality assurance.
The typical work activities undertake in this field include:
- planning and organizing work in clinical biochemistry laboratories
- carrying out complex analyses on specimens of body fluids and tissues
- assuring the quality of clinical biochemistry investigations
- auditing the diagnostic and clinical use and performance of investigations
- developing new and existing tests, often automated and computer assisted but sometimes requiring considerable manual expertise
- liaising with clinical and other healthcare staff, often in a multidisciplinary team setting
- some patient contact
- writing reports
- Submitting funding bids and conducting research with clinicians.
In addition to their role in diagnostics, clinical biochemists also work at the forefront of research and innovation, so that patients continually receive the best healthcare. For example, in clinical biochemistry, they are involved in identification of new molecular and/or protein biomarkers; the development of new methods and the design of drug delivery, innovative models of service provision, in identifying novel therapeutic targets for various diseases including cancer and Coronary vascular diseases. Increasingly, clinical biochemistry is being applied to keeping people healthy and preventing disease; and to enabling health professionals to monitor various parameters which in individuals with chronic disease and thus to timely modify the management strategies.
The following equipments have been installed in the department till date:
i. HPLC system ii. Automated PCR
iii. Realtime PCR iv. Spectrophotometer
v. Flowcytometer vi. Nephlometer
vii. Ultra Centrifuge viii. Cell Centrifuge
ix. Geldocumentation System x. Proteomics System
xi. Spectrometer xii. Micro array
xiii. Electrochemi xiv. Microscope-Trinocular, Inverted, Confocal
xv. Autoanalyzer xvi. Blood Gas Analyzer
xvii. Electrolyte Analyzer xviii. Atomic absorption spectrophotometer
xix. CO2 incubator xx. -800C Deep Freezer
xxi. Ice Flecker xxii. -200C Deep Freezer
xxiii. PCR xxiv. Laminar Airflow
xxv. Proteomics System xxvi. Microarray
xxvii. Confocal Microscope xxviii. GMP facility for Stem Cell
xxix. Mass Spectrometry
Available test facilities:
• Glucose • Creatinine • Albumin • Magnesium
• Urea • AST(SGOT) • Globulin • Cholesterol (T)
• ALT(SGPT) • Bilirubin(D) • Uric acid • Triglyceride
• Alk.Phosphate • Bilirubin(I) • Calcium • HDLc
• Bilirubin(T) • T.Protein • Phosphorus • LDLc
• VLDLc • Na(Sodium) • K(Potassium) • Cl(Chloride)
• Amylase • CSF chemistry • Body fluids chemistry • 24 hr. urine- proteins
• Creatinine clearance • 24 hr urine analysis • ABGs/VBGs • HIV - PCR,
• TB - PCR • TB – IgM • T3, T4, TSH • LH, FSH, PRL
• Testosterone • Progesterone • Estradiol • CD3/CD4/CD8 count
• CD3/CD4/CD45 count (NACO) • HLA-B-27 • Sickling Solubility Test • Hb Electrophoresis
• Hb Variant (HPLC) • PCR diagnostic (selected disease only) • Protein electrophoresis • AFB/BHCG/CEA/PSA
• CA125/CA15-3/ CA19-9 • Iron/TIBC/Ferittin • Folic acid/Vitamin B12 • Insulin
• Cortisol • Glycosylated Hb • ANA/Ds DNA • Protein electrophoresis
• CK -MB • Pro BNP • Troponin T • LEUKEMIA MARKER
Conferences and Workshops conducted :
1. Conference on July 2004 of "Association of Medical Biochemist of India"
2. Symposium on July 25, 2006 on "Biotechnology in Future Medicine"
3. Symposium on July 25, 2007 on "Stem Cell in Future Medicine"
4. Symposium on July 25, 2008 on "Trends on Regenerative & Molecular Medicine"
5. Symposium on July 25, 2009 on "Trends in Genetic & Personalized Medicine"
6. Symposium on July 25, 2010 on "Role of Microarray in Future Medicine"
7. International Conference on Sickle cell disease, Nov. 22-27, 2010 on "Management & Prevention of sickle cell disease in developing societies".
8. Symposium on July 25, 2011 on "Cell Therapy"
9. Symposium on July 25, 2012 on "Cord Blood Banking"
10. International conference on molecular Pathology & 2nd Annual Conference of MPAI. on 9th & 10th Feb. 2013 on "Role of Molecular Diagnosis In Prevention & Treatment of Genetic And Metabolic Disorders"
11. Symposium on July 25, 2014 on " Digital Medicine"
12. Symposium on July 2015 Quality Control In Medicine
13. Symposium on 25th January 2016 on ‘Genome to drug’ And 3rd AMBICON-CG state chapter.
1. 04-06 Nov. 2004 on "Variant Haemoglobin Testing System"
2. 26-31 July 2006 on "Autosmated PCR"
3. 26-31 July 2007 on "Flowcytometer"
4. 26-31 July 2008 on "DNA Sequencing"
5. 26-31 July 2009 on "Proteomics"
6. 26-31 July 2010 on "Microarray"
7. 16-18 Jun. 2011 on "Sickle Cell Solubility and Electropheresis"
8. 26-31 July 2011 on "Cell Manipulation & Confocal Microscopy"
9. 26-31 July 2012 on "Stem Cell & Flowcytometry (Analyser & Sorter) "
10. 7-8 Feb. 2013 "Application of Cytogenetics in Clinical Practice."
11. 26-31 July 2013 on "Microarray & Real Time PCR Techniques."
12. 26-31 July 2014 on " Bioinformatics in Medical Sciences."
13. 26-july-1st August 2015 on “Molecular Diagnostics”
14. 26th January-1st February 2016 on “
Head of Department
|Name||Dr. P.K. Patra|
|Designation||Professor & Head of Department|